A Brief Guide To Freeze Drying

Freeze-drying—technically known as lyophilisation, lyophilization, or cryodesiccation—is a dehydration process typically used to preserve a perishable material or make the material more convenient for transport. Freeze-drying works by freezing the material and then reducing the surrounding pressure to allow the frozen water in the material to sublimate directly from the solid phase to the gas phase.

Properties of freeze-dried products:

If a freeze-dried substance is sealed to prevent the reabsorption of moisture, the substance may be stored at room temperature without refrigeration, and be protected against spoilage for many years. Preservation is possible because the greatly reduced water content inhibits the action of microorganisms and enzymes that would normally spoil or degrade the substance.

Freeze-drying also causes less damage to the substance than other dehydration methods using higher temperatures. Freeze-drying does not usually cause shrinkage or toughening of the material being dried. In addition, flavours, smells and nutritional content generally remain unchanged, making the process popular for preserving food. However, water is not the only chemical capable of sublimation, and the loss of other volatile compounds such as acetic acid (vinegar) and alcohols can yield undesirable results.

Freeze-dried products can be rehydrated (reconstituted) much more quickly and easily because the process leaves microscopic pores. The pores are created by the ice crystals that sublimate, leaving gaps or pores in their place. This is especially important when it comes to pharmaceutical uses. Freeze-drying can also be used to increase the shelf life of some pharmaceuticals for many years.

Pharmaceutical and biotechnology:

Pharmaceutical companies often use food freeze dryer to increase the shelf life of the products, such as vaccines and other injectables. By removing the water from the material and sealing the material in a vial, the material can be easily stored, shipped, and later reconstituted to its original form for injection. Another example from the pharmaceutical industry is the use of freeze drying to produce tablets or wafers, the advantage of which is less excipient as well as a rapidly absorbed and easily administered dosage form.

Freeze drying equipment:

There are essentially three categories of freeze-dryers: the manifold freeze-dryer, the rotary freeze-dryer and the tray style freeze-dryer. Two components are common to all types of freeze-dryers: a vacuum pump to reduce the ambient gas pressure in a vessel containing the substance to be dried and a condenser to remove the moisture by condensation on a surface cooled to −40 to −80 °C (−40 to −112 °F). The manifold, rotary and tray type freeze-dryers differ in the method by which the dried substance is interfaced with a condenser. In manifold freeze-dryers a short usually circular tube is used to connect multiple containers with the dried product to a condenser. The rotary and tray freeze-dryers have a single large reservoir for the dried substance.

Follow On:-

Quality Output With Stick Packing Machine & Sachet Packing Machine

The taste of candy stick will be so mesmerizing and attractive that no one else in the world will be missing the taste. Packing the stick in the perfect order and in the perfect sequence is not a simple task as many people are thinking. There will be a number of difficulties present in this process. If the process of stick packing is done with the help of manual labor, it will take more time for the process of packing. It is a hard necessity for the industry to make use of the advanced models of Stick Packing Machine. The best thing about the packing machine is that it will provide best production line for the sequencing of the packages in perfect order and it is also very easy to sort out the production line in certain order for shuffling the flavor. Compared to the old model of Stick Packing Machine, the current version is far more powerful and it will do things in the speed of lightning.

Sachet has become one of the most popular forms of marketing in the recent days. Starting from shampoo to cooking oil, it is now very common to find sachets available in many places. The process of filling sachet takes more time and effort to make sure that the content and the sealing has been done in a perfect manner. To assist people in doing it in a perfect manner, Sachet Packaging Machine is now available. Depending on the size and the demand, there are different types of machines now available with different capacity and also the speed of production line. Depending on the demand of customer, customization can be done in a number of features of the machine.

In order to preserve the food products that are going to be stored for a long period of time, the food processing industry must remove the heat out of the production process immediately and freeze the food to make sure that it is not being decayed or getting contact with the harmful micro organisms that are present in the atmosphere. With the help of simple and powerful Food Freeze Dryer, preserving food is not a matter of concern. It is very much useful for processing solid based food items. Filling chocolates in the respective container is one of the processes that need to be done in a careful manner. If there is any loss in the weight of the chocolate, it will impact hardly in the marketing chain. Advanced models of One-shot chocolate depositing production line can help the industry to improve the processing capacity to a great extent. It is most suitable for mass manufacturing of best quality chocolates. The quality and quality of the chocolate will be preserved as it is.

 

Follow On:-

A Brief Guide to The Tablet Coating Procedure

A lot of solid pharma dosage mediums are manufactured with coverings, either on the outer surface of the capsules, or on substances distributes within gelatin pills. Tablet coating caters a great deal of purposes:

• Safeguards the capsule form abdomen acids

• Safeguards the abdomen lining from volatile drugs like enteric covered aspirin.

• Offers a delayed discharge of the drug

• Assist sustain the shape of the capsule

Preferably, the capsule must discharge the substance steadily and the medication must be accessible for digestion beyond the abdomen. The covering can be formulated specially to control how quickly the capsule melts and where the accessible medications are to be immersed into the body following eating.

Several aspects can influence the end-use properties of pharma capsules:

• Coating procedure

• Chemical composition

• Storage & environmental monitoring

• Drying period

Coating procedure design and control:

Tablet film coating system happens in a regulated ambiance within a punctured revolving drum. Slanting baffled slotted into the drum & airflow within the drum offer modes of blending the capsule bed. Consequently, the capsules are raised and turned from the sides into the hub of the drum, revealing each capsule surface to a constant volume of deposited coating.

Then the liquid spray covering is dried onto the capsules by heated air driven via the capsule bed from an inlet fan. The flow of air is controlled for heat and volume to offer controlled drying & extracting tempos, and at the same time, sustaining the drum pressure a little negative relation to the room to offer an absolutely isolated ambiance to the operator.

Tablet coating tools may comprise coating pan, cartooning machine, polishing pans. Blenders & mixtures, mills, fans, steam jackets, homogenizers, exhaust & heating pipes, filters and scales. Table coating practice may comprise sugar coating or film coating.

The coating practice is generally a batch impelled job including the below mentioned phases:

• Batch identification & recipe selection

• Loading or dispensing

• Warming

• Spraying

• Drying

• Cooling

• Unloading

A control unit should thus offer adaptability in the way in which precise & recurring regulation of the coating ambiance is accomplished and will comprise the below mentioned features:

• Accurate loop control with set point profile programming

• Chronological control for complicated control strategies

• Recipe management system for simple parameterization

• Safe accumulation of online data from the coating unit for analysis & evidence.

• Local operator display with apparent graphics & controlled access to limitations.

Follow On:-

Tablet Press Machines and Their Applications in the Pharmaceutical Industry

You must have come across different sorts of tablets such as small, big, square, round, etc. tablet press machine or table compression machinery is the mechanical wonder which offers tablet accurate shape & size. A tablet press is an automatic tool that squeezes powder into tablets of various weight and size.

To produce regular sized tablets the granulated substance is pushed into the cavity with 2 punches pushed collectively. In this device you can fine tune lower & upper punches so the weight, size and compactness can be sustained uniformly. tablet deduster machine is composed string of rollers, punches and carns, and occasionally for filling & ejecting capsules some automatic systems are also integrated. The company which makes this sort of machinery are professional in making containers which are measured in a cautious manner for accurate weight control.

Tablet Press machines should be effortless to clean and fast to rearrange in cosmetic and pharmaceutical industries, since they require to be uncontaminated following each & every batch. That is why they’re manufactured in such a way that they can be cleaned easily and quickly.

There’re mainly of 2 kind’s single punch or rotary type:

Single punch table press machines are employed in lab pharmaceutical productions – like effervescent tablets, compressed tablets and chewable tablets.

Rotary tablet press machines are affordable and widely used in the pharmaceutical industry. They’re employed for products such as sugar pieces, chewable tablets, etc.

Some essential features of table press machine are:

• Quality production accomplished at high speed functions

• The body is protected in cabinet – so the entire operation is free of dust.

• Simple & convenient function, providing operator protection, hygiene and ease of preservation.

• All limitations of the function can be adjusted from tableting area placed outside of the device.

• Table press machines are made of high-quality substances which makes them decay free machines.

Last but not the least when you are looking to buy a tablet press machine, try to find an authentic supplier of such machines. Since there are so many manufacturers available you may get confused which one to choose. You may also want to make sure the vendor you are dealing with is a recognized one. Therefore, you shouldn’t shy to waste some time in research. The internet is packed with information and no doubt it is the best place to get a comprehensive list of table press machine manufacturer. So do your research and stay safe & free!

Follow On:-

What Makes Blister Packing So Popular In the Pharma Industry

The pharmaceutical industry is quite large and comprised of a great deal of diverse firms. As per the statistics accumulated by Statistic Brain, 3 of the most important manufacturers (Pfizer, AstraZeneca, and Bristol-Meyers Squibb Co.) all have a single medicine that produces more than $4.5 billion a year in sales. But regardless of their size, and the gigantic character of the industry as a whole, much less noticeable pharmaceutical packaging firms are hugely important. They provide several pharma packaging choices that assist makers ensure consumers securely get their drugs.

Though sachets, pouches, and bottle packing are all standard, pharma blister packings tend to be the finest option. Therefore, blister packing machines are in huge demand in the pharma industry these days. Blister packing provides a variety of diverse advantages that help it more dependable, and in result, more recognized than others. Let’s have a look at a few advantages of blister packings:

• Blister packings are safe to safeguard items from gas and moisture, to make sure a long shelf life, in stores & drug cabinets likewise. Durability is vital for customers who wish to keep drugs on-hand when problems take place.

• Pharma blister packing is economical and effortless to generate in a greater quantity. As a result, it’s an excellent option for some of the renowned drug manufacturers.

• Supportive to consumers since they offer a sanitized area for directives to be inscribed and easy-to-follow.

• Blister packings are effortless to make use of. Usually, users have to do is pop the capsule out of the pack, which can be accomplished rather quickly. For additional convenience, there’re senior-friendly solutions & augmented safety with childproof features.

• There’s a wide array of colors & finishes that blister packing can be constructed to feature. Makers can utilize that to assist make their product stand out on shelves.

• Carded blister packing choices are also idea for marketing since they permit either the makers or traders to comprise promotional substances to help construct a brand & increase consumer trustworthiness.

The worldwide pharma industry is anticipated to be worth more than a trillion dollars at some extent this year according to a research from Urch Publishing. Though packing machineries such as capsule filling machines, blister packing machines, etc are usually ignored, particularly by customers, they will play a crucial part in assisting manufacturers fulfill the increasing demand of consumers in the near future – there is no doubt about that.

Follow On:-

The Challenges In Pharmaceutical Packaging

When it comes to challenges of pharmaceutical packaging the foremost thing that comes in mind are the issues related to the protective means for controlling contamination. This is exactly where most of the pharmaceutical packaging companies face trouble. Once, the pharmaceutical products roll off the production companies, the concern to protect the products from contamination shifts to the packaging industry.

With the arrival of several life saving drugs, one of the major issues that many pharmaceutical packaging companies are facing is producing primary packaging components, which are compatible with the chemical components forming the products. Many of the elements in the drugs are highly sensitive to certain ingredients. Hence, the products have to be sealed and packed to avoid any leakage.

Pharmaceutical packaging has always been innovative and creative, with new technologies bringing up a variety of packaging models such PET bottles and blister packs, among others. Several cost effective solutions have also been introduced to make pharmaceutical packaging more affordable. Consumers are more conscious about the quality of pharmaceutical products and their visual appearance. Therefore, manufacturers need to take these issues seriously and ensure quality packaging as well.

Pharmaceutical packaging is more than just filling the content into a colorfully designed and labeled container. It demands an extreme degree of safety until the product reaches the end users and brought to use. Therefore, it is very different from other commercial product packaging. The prime focus of the packaging is to protect the drug content from harmful external elements with different protection levels and make it perfectly safe for shipping and distribution.

The stability of the products and the compactness of chemical composition entirely depend on how the drugs are packed. Ideally, there is no exact material that can guarantee to balance drug properties. It is experience, knowledge of materials and judgment of the pharmaceutical packaging company that determines the success of the pharmaceutical products.

There are many drugs which are highly sensitive to sulfur. Being a common component in few rubber elastomeric formulations, it is another challenge for pharmaceutical packaging. Other than sensitivity what matters the most in pharmaceutical packaging is the way the products are going to be used. The packaging of the drugs highly depends on their uses. Take stopper and vial as instances. Packaging companies need to know that how the products will to be used when landed between the end users. If packaging companies are unaware of the kind of needle to be used or confused whether they will be a multi-dose application, it is really difficult to handle the issue once they are in the field. Such issues generate problems because the chemical composition is typically proportionate during their stability.

To buy a whole range of reliable pharma packing machines including sachet packaging machine, blister packing instrument, Food freeze dryer, cartooning machines, etc contact SaintyCo – China’s leading manufacturer of pharmaceutical instruments.

Follow On:-

Stick Packs – Beneficial Both For The Consumer And Environment

Stick packs have brought a new portability to the market. Sometimes referred to as On-the-Go or “single serve”, these packs offer a expediency over other forms of food packaging. These single serve packs derive their name from their long, skinny shape that resembles a stick of gum.

Single serve packs are made from a supple foil that are filled vertically and sealed at both ends and down the back to form a little pouch. Unlike sachets, stick packs are narrow which makes it simple to pour the contents of the package into the neck of a bottle of water. An individual pack also holds a single serving and simply fits into a backpack or purse.

Stick packs or stick-pouches have been around since the 70’s. In Japan & Europe they have been established since the early 1990’s. These stick pouches have begun to take hold as a new category due to the surge in demand for flavorings and additives for a more active user. Nowadays these packs reach far beyond sugar substitutes to include flavored drink mixes, energy drinks, vitamin supplements as well as diet drink mixes.

A chief benefit of a these packs are the controlled portion aspect. With consumers being as active as they are they do not have time to measure specific amounts for each usage. Single serve packs take care of that problem by having the correct dosage in every stick. Each individual stick preserves freshness while eliminating any waste for the consumer. Also, since they are not sold individually the consumer can purchase a month worth at a time.

Beyond portability these foils also have a smaller result on the environment as compared to other types of packaging. When compared with a traditional pouch the savings can be up to 35 percent on just the cost of film. These are the reasons why the demand Stick Packing Machine are increasing day by day.

Stick packs provide many benefits to both the consumer and the environment. Due to their low per-item cost and controlled portions stick packs provide a very economical and great tasting solution for the consumer.

Follow On:-

A Lot Of Changes Have Made To The Tablet Coating System

Pharmaceutical coating is a vital technique in manufacturing pills and other medicines. As the pharmaceutical industry develops, the coating techniques continue to move forward. Initially, sugar-coating was very popular in order to give more likable taste and more striking look to tablets, as well as alleviating the bitterness of drugs that are not pleasant. These days, a lot of coating forms have been developed, like tablet film coating system which puts off the release of the drug until it gets to the intestines. Although pharmaceutical coating is a complicated process, it continues up till today to improve the stability or modify the release of drugs.

Modern coatings make use of film coating made from cellulose derivatives like hydroxyproply methylcellulose or other cellulose polymers like acrylic polymers, cellulose ethers and infrequently-used materials like polyvinyl alcohol or polyethylene glycols and other waxy materials. A film coating is a thin, polymer-based coat that is applied to a tablet and when the film structure is closely examined, it is frequently non-homogenous, which is the result of intentional addition of insoluble pigments for coloring and from the recurring coating process.

There are four types of coating: sugar coating, film coating, micro encapsulation and compression. Coating is usually the last process in tablet manufacturing process. Sometimes, the process of splitting the pills follows, which is done to produce a lower dose of the active ingredient.

Since sugar coating process could take up to five days, there was need to come up with alternative methods of pharmaceutical coating. Some of the problems associated with sugar pills are high level of required operator skills, lengthy process and intricacies in labeling tablets with logo and product name. As a result of this, a lot of changes have come into sugar coating, for example, the use of atomizing systems for spray-on sugar coating, air suspension techniques, more efficient drying systems and the use of aluminum dyes to improve evenness of color. Compression coating was also developed where core-coating material is compressed round the core of the pill.

There has also been tremendous improvement in other medical device coatings which has led to better service delivery in the industry. Since the pharmaceutical industry is part of the medical field, it is important to get it right with coating.

If you are looking for n effervescent tablet film coating system or other pharmaceutical tools like cartooning machine,tablet deduster, etc contact SaintyCo – a leading manufacturer of all pharma related instruments.

Follow On:-

Blister Packing Machines And Their Use In The Pharma Industry

Blister packs and plastic products are quite useful for packaging in the pharmaceutical industry. Both of them have a set of advantages that no other material can afford to give. From their ease of use to the varieties, there are plenty of advantages.

There are basically four types of production of blister packaging. They include thermodynamic, cold forming, Polyvinyl Chloride (PVC) and Cyclic-olefin-co polymers (COC) or polymers (COP). However, none of these types affects the functionality or even the look. Their main application is the unit packaging that we can see in pharmaceutical tablets, capsules and lozenges.

Blister Packing Machine is commonly used as unit-dose packaging for pharmaceutical tablets, capsules or lozenges. Blister packs can provide barrier protection for shelf life requirements, and a degree of tamper resistance. In the US, blister packs are mainly used for packing physician samples of drug products or for over-the-counter (OTC) products in the pharmacy. In other parts of the world, blister packs are the main packaging type since pharmacy dispensing and re-packaging are not common. A series of blister cavities is sometimes called a blister card or blister strip as well as blister pack. The difference between a strip pack and blister pack is that a strip pack does not have thermo-formed or cold formed cavities; the strip pack is formed around the tablet at a time when it is dropped to the sealing area between sealing moulds. In some parts of the world the pharmaceutical blister pack is known as a push-through pack (PTP), an accurate description of two key properties (i) the lidding foil is brittle, making it possible to press the product out while breaking the lidding foil and (ii) a semi-rigid formed cavity being sufficiently collapsable to be able to dispense the tablet or capsule by means of pressing it out with the thumb.

The main advantages of unit-dose blister packs over other methods of packing pharmaceutical products are the assurance of product/packaging integrity (including shelf-life) of each individual dose and the ability to create a compliance pack or calendar pack by printing the days of the week above each dose.

Blister packs are created by means of a form-fill-seal process at the pharmaceutical company or designated contract packer. A form-fill-seal process means that the blister pack is created from rolls of flat sheet or film, filled with the pharmaceutical product and closed (sealed) on the same equipment. Such equipment is called a blisterline. There are two types of blister machine’ design: rotary and flat-plate.

To buy affordable blister packing and Capsule Filling Machine shop online rather offline. There are lots of online retailers offering good discount on different pharmaceutical devices.

Follow On:-

Tablet Press Machine – The Most Valuable To the Pharma Industry

If you’re company is part of the pharmaceutical industry, particularly on the manufacturing side of things, you are going to need to find the correct equipment and some reliable providers from which to purchase your equipment. You can often pick up used equipment from pharmaceutical manufacturers that are upgrading equipment. Here in this article we are going to discuss about tablet press machine and their importance to the pharma industry.

A tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, illicit drugs such as MDMA, cleaning products, and cosmetics. To form a tablet, the granulated material must be metered into a cavity formed by two punches and a die, and then the punches must be pressed together with great force to fuse the material together.

There are 2 types of Tablet Presses: single-punch and rotary tablet presses. Most high speed tablet presses take the form of a rotating turret that holds any number of punches. As they rotate around the turret, the punches come into contact with cams which control the punch’s vertical position. Punches and dies are usually custom made for each application, and can be made in a wide variety of sizes, shapes, and can be customized with manufacturer codes and scoring lines to make tablets easier to break. Depending on tablet size, shape, material, and press configuration, a typical modern press can produce from 250,000 to over 1,000,000 tablets an hour.

Mini tablet presses which are available with the suppliers’ are ideal for pharmaceutical application that reflects small scale productions. These machines offer trouble free operation and come with the feature of easy to maintain. About performance, it can be used for the manufacturing of hundreds of tablets without creating any noise. In various technical specifications, these machines are available after they are stringently tested as per quality industrial standards.

Numerous pharmaceutical companies are available in China which are providing tablet press or tablet deduster with quality features and affordable rates. But, to get the latest and high-quality tablet punch machines, go through various online companies and avail the best one at affordable rates to serve the purpose of Pharmaceuticals without burning a hole in your pockets.

So, don’t hang around anymore. Go online and look for the most reliable manufacturer of table press machine. Best of luck!

Follow On:-